Suppression of symptoms of alcohol dependence and craving using high-dose baclofen.
نویسنده
چکیده
AIMS To further test whether the baclofen-induced suppression of motivation to consume alcohol in animals could be transposed to humans. METHODS A patient who had neither tolerated nor benefited from other alcohol treatment modalities was put on trial with baclofen on a dosage up to 140 mg/day. RESULTS The patient reported dramatic reduction in cravings for and preoccupation with alcohol. CONCLUSIONS High-dose baclofen therapy was associated with complete and prolonged suppression of symptoms and consequences of alcohol-dependence.
منابع مشابه
Case Report Complete and Prolonged Suppression of Symptoms and Consequences of Alcohol-dependence Using High-dose Baclofen: a Self-case Report of a Physician
Aims: To test whether the dose-dependent motivation-suppressing effect of baclofen in animals could be transposed to humans, and suppress craving and sustain abstinence. Methods: Neurologists safely use up to 300 mg/day (10 times the dosage currently used for alcohol dependence) of high-dose oral baclofen, to control spasticity, in order to avoid invasive therapy. I am a physician with alcohol ...
متن کاملCase Report Suppression of Symptoms of Alcohol Dependence and Craving Using High-dose Baclofen
Aims: To further test whether the baclofen-induced suppression of motivation to consume alcohol in animals could be transposed to humans. Methods: A patient who had neither tolerated nor benefited from other alcohol treatment modalities was put on trial with baclofen on a dosage up to 140 mg/day.Results: The patient reported dramatic reduction in cravings for and preoccupation with alcohol. Con...
متن کاملComplete and prolonged suppression of symptoms and consequences of alcohol-dependence using high-dose baclofen: a self-case report of a physician.
AIMS To test whether the dose-dependent motivation-suppressing effect of baclofen in animals could be transposed to humans, and suppress craving and sustain abstinence. METHODS Neurologists safely use up to 300 mg/day (10 times the dosage currently used for alcohol dependence) of high-dose oral baclofen, to control spasticity, in order to avoid invasive therapy. I am a physician with alcohol ...
متن کاملSuppression of Alcohol Dependence Using Baclofen: A 2-Year Observational Study of 100 Patients
AIMS The purpose of this study was to examine the long-term effects of baclofen in a large cohort of alcohol-dependent patients compliant to baclofen treatment. METHODS A hundred patients with alcohol dependence, resistant to usual treatments, were treated with escalating doses of baclofen (no superior limit). Alcohol consumption (in grams) and craving for alcohol were assessed before treatme...
متن کاملLETTER TO THE EDITOR Response to Ameisen
We thank Dr Ameisen for his interest on our manuscript (Addolorato et al., 2011) and appreciate the opportunity to respond to his comments. As noted by Dr Ameisen (Ameisen, 2011), in our manuscript, we refer not only to his case report (Ameisen, 2005), but also to the case report by Bucknam (2007). We appreciate Dr Ameisen’s clarification that in his own case report high-dose baclofen suppresse...
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ورودعنوان ژورنال:
- Alcohol and alcoholism
دوره 42 2 شماره
صفحات -
تاریخ انتشار 2007